Sunday, September 25, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Duke Dawson | DB | Sun, Sep 25 | Groin | Questionable for Week 4 vs. Arizona |
| Andrew Parchment | WR | Sun, Sep 25 | Undisclosed | Questionable for Week 4 vs. Arizona |
| Jacob Tuioti-Mariner | DT | Sun, Sep 25 | Knee | Questionable for Week 4 vs. Arizona |
Tuesday, September 20, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Andre Roberts | WR | Tue, Sep 20 | Knee - PCL | IR. Injured Reserve. | Week 6 |
| Bravvion Roy | DT | Tue, Sep 20 | Hamstring | IR. Injured Reserve. | Week 7 |
Saturday, September 17, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Matt Corral | QB | Sat, Sep 17 | Foot | IR. Injured Reserve |
Wednesday, September 7, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Sam Darnold | QB | Wed, Sep 7 | Ankle | IR. Injured Reserve. | Week 5 |
Wednesday, August 31, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Julian Stanford | LB | Wed, Aug 31 | Undisclosed | IR. Injured Reserve |
Tuesday, August 30, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Zane Gonzalez | K | Tue, Aug 30 | Groin | IR. Injured Reserve |
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