Isaac Guerendo waiver wire fantasy outlook Week 14: Should you add 49ers RB to replace Christian McCaffrey?

Week 13 was clearly not kind on the San Francisco 49ers. Between racking up yet another loss, effectively condemning their playoff hopes to the basement, and losing two running backs to injury, coach Kyle Shanahan will have more than a few headaches to deal with in Week 14.

When Christian McCaffrey went down with an injury, the hope was that it wasn't a long-term one. However, further diagnosis revealed that the All-Pro running back picked up a posterior cruciate ligament (PCL) injury which could potentially be a season-ending one. To compound matters for Shanahan, backup running back Jordan Mason also ended up on the injured reserve list with a high ankle sprain.

McCaffrey only made his season debut in November after missing the first eight games of the year owing to an Achilles injury. He suited up in four games for the Niners, registering 202 yards on 50 carries. He also hauled in 15 receptions for 146 yards. In any case, the Niners will now have to turn to RB3 Isaac Guerendo as they fight to keep their slim playoff hopes alive. But if you are in a position to bring Guerendo on board in your fantasy leagues, here's why you shouldn't think twice.

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Isaac Guerendo waiver wire outlook for fantasy Week 14

Considering McCaffrey was the Niners' leading rusher in his first three games back, his absence will likely force Kyle Shanahan to alter his plans for the weeks ahead.

But Shanahan could wait a week to do that. They face the Chicago Bears next week, a team that has struggled to defend the run.

In addition, on Sunday night, Guerendo had the Niners' lone TD off a 15-yard run so they clearly have no qualms about handing him the ball when it comes right down to it. Guerendo filled in admirably earlier as well when, in Week 8, the Niners turned to him to lead the offense on the ground.

The fantasy football playoffs will kick off in Week 15 but you don't need to wait that long to swoop for Guerendo, who will be primed to deliver well above his potential off the waiver wire.