| Date | Match | Time (ET) |
| October 4, 2018 | Indianapolis Colts vs New England Patriots | 8:20 PM |
| October 7, 2018 | Tennessee Titans vs Buffalo Bills | 1:00 PM |
| October 7, 2018 | New York Giants vs Carolina Panthers | 1:00 PM |
| October 7, 2018 | Miami Dolphins vs Cincinnati Bengals | 1:00 PM |
| October 7, 2018 | Baltimore Ravens vs Cleveland Browns | 1:00 PM |
| October 7, 2018 | Green Bay Packers vs Detroit Lions | 1:00 PM |
| October 7, 2018 | Jacksonville Jaguars vs Kansas City Chiefs | 1:00 PM |
| October 7, 2018 | Denver Broncos vs New York Jets | 1:00 PM |
| October 7, 2018 | Atlanta Falcons vs Pittsburgh Steelers | 1:00 PM |
| October 7, 2018 | Oakland Raiders vs Los Angeles Chargers | 4:05 PM |
| October 7, 2018 | Minnesota Vikings vs Philadelphia Eagles | 4:25 PM |
| October 7, 2018 | Arizona Cardinals vs San Francisco 49ers | 4:25 PM |
| October 7, 2018 | Los Angeles Rams vs Seattle Seahawks | 4:25 PM |
| October 7, 2018 | Dallas Cowboys vs Houston Texans | 8:20 PM |
| October 8, 2018 | Washington Redskins vs New Orleans Saints | 8:15 PM |
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