| Date | Match | Time (ET) |
| October 18, 2018 | Denver Broncos vs Arizona Cardinals | 8:20 PM |
| October 21, 2018 | Tennessee Titans vs Los Angeles Chargers | 9:30 AM |
| October 21, 2018 | New England Patriots vs Chicago Bears | 1:00 PM |
| October 21, 2018 | Buffalo Bills vs Indianapolis Colts | 1:00 PM |
| October 21, 2018 | Houston Texans vs Jacksonville Jaguars | 1:00 PM |
| October 21, 2018 | Cincinnati Bengals vs Kansas City Chiefs | 1:00 PM |
| October 21, 2018 | Detroit Lions vs Miami Dolphins | 1:00 PM |
| October 21, 2018 | Minnesota Vikings vs New York Jets | 1:00 PM |
| October 21, 2018 | Carolina Panthers vs Philadelphia Eagles | 1:00 PM |
| October 21, 2018 | Cleveland Browns vs Tampa Bay Buccaneers | 1:00 PM |
| October 21, 2018 | New Orleans Saints vs Baltimore Ravens | 4:05 PM |
| October 21, 2018 | Dallas Cowboys vs Washington Redskins | 4:25 PM |
| October 21, 2018 | Los Angeles Rams vs San Francisco 49ers | 8:20 PM |
| October 22, 2018 | New York Giants vs Atlanta Falcons | 8:15 PM |
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