Offensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Quarterback | Geno Smith | Drew Lock | — |
| Running Back | Kenneth Walker III | Travis Homer | DeeJay DallasTony JonesRashaad Penny |
| Fullback | Nick Bellore | — | — |
| Wide Receiver | DK Metcalf | Tyler Lockett | Marquise GoodwinD'Wayne EskridgePenny HartDareke YoungCody Thompson |
| Tight End | Will Dissly | Noah Fant | Colby Parkinson |
| Left Tackle | Charles Cross | Stone Forsythe | — |
| Left Guard | Phil Haynes | Damien Lewis | — |
| Center | Austin Blythe | Kyle Fuller | — |
| Right Guard | Gabe Jackson | — | — |
| Right Tackle | Abraham Lucas | Jake Curhan | — |
Defensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Left Defensive End | Quinton Jefferson | Shelby Harris | — |
| Nose Tackle | Al Woods | Bryan Mone | — |
| Right Defensive End | Myles Adams | Poona Ford | L.J. Collier |
| Left Inside Linebacker | Jordyn Brooks | Nick Bellore | Cullen GillaspiaJon Rhattigan |
| Right Inside Linebacker | Cody Barton | Nick Bellore | — |
| Strongside Linebacker | Uchenna Nwosu | Boye Mafe | Joshua OnujioguTyreke Smith |
| Weakside Linebacker | Darrell Taylor | Bruce Irvin | Alton RobinsonDarryl Johnson |
| Right Cornerback | Tariq Woolen | Coby Bryant | Artie BurnsTre Brown |
| Left Cornerback | Mike Jackson | Justin Coleman | Isaiah Dunn |
| Strong Safety | Ryan Neal | Josh Jones | Jamal Adams |
| Free Safety | Quandre Diggs | Joey Blount | Teez Tabor |
Special Teams Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Punter | Michael Dickson | — | — |
| Kicker | Jason Myers | — | — |
| Long Snapper | Carson Tinker | — | — |
| Holder | Michael Dickson | — | — |
| Punt Returner | D'Wayne Eskridge | — | — |
| Kick Returner | DeeJay Dallas | Kenneth Walker III | — |
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