Top 5 NFL quarterbacks with the most losses against Tom Brady

2. Ryan Fitzpatrick (10)

Fitzpatrick and Brady after a December 2016 meeting in New England (Photo: Getty)

No matter where the well-traveled Fitzpatrick ended up, he couldn't escape the ire of Brady, whose AFC East monopoly positioned him in a matchup with the Harvard alum on 13 occasions, making him his most common regular-season foe. Fitzpatrick is a Flying Elvis helmet away from completing divisional bingo, as his NFL career has taken him to the eastern haunts of Buffalo, Miami, and New York, earning one win against Brady and the Patriots at each locale. Despite his lack of success on the scoreboard, Fitzpatrick has earned 21 career touchdown passes against the Patriots, his best tally against any opponent.

1. Peyton Manning (11)

Brady and Manning after their final postseason meeting in 2016 (Photo: Getty)

Conjoined at the gridiron hip by their shared greatness, Brady and Manning staged one of the greatest and longest-running individual showdowns in NFL history. Brady's first NFL triumph, in fact, came against Manning: his first full-time substitution effort in place of Drew Bledsoe led to a 44-13 blowout win over the Colts in September 2001. Their get-togethers spanned three cities, with Manning's greatness taking him to both Indianapolis and Denver. Though Brady won 13 of the 19 regular season showdowns, Manning denied Brady three additional Super Bowl rings. Along with his brother Eli and former Baltimore Raven Joe Flacco, Manning is part of an exclusive club that has beaten Brady in the postseason more than once.